Alice was an English nine-year old who suffered head trauma. The team examining the CT scan to design the cranial Scaffold noted a brain swelling and reported it to the doctor. This believed that he could suck out some spinal fluid, so has to reduce brain pressure and help mount the implant. Once in the operating theatre, it turned out the brain swelling was not due to fluid accumulation, but to natural brain growth. They decided to still use the implant adjusting it to the cranial cavity as far as possible.

As time went by, though, a slight asymmetry started showing in Holly's skull due to brain growth. The team went back to work to correct that defect and created a more curved implant than the previous one, which allowed the grown brain to be mounted without imperfections. Alice's second surgery revealed a fact of scientific interest: after just a year from the first operation Alice's bone had already restarted to grow, which highlighted the benefit of using a bio-material like ceramics for this kind of implant. This surgery shows that ceramic implants ensure an optimal outcome restoring the natural condition of the damaged bone.