CustomBone Service (CBS) is a patient-specific cranial implant made of hydroxyapatite (HA), a CaP-derivative with chemical features and a 3D porous structure which resembles the mineral component of human bone. 

Compared to other alloplastic alternatives on the market (i.e. PMMA, PEEK, Titanium), these peculiar properties make CBS a good candidate for replacing cranial bone defect in a physiological manner.  

The HA macro, interconnected and micropores sustain the formation of a biochemical continuity with the host bone tissue [1], which play a role in new bone ingrowth and bone regeneration, making the material suitable for cells housing. 
Thanks to the high porosity, the device can also be loaded with antibiotics in the intra-operative phase. For the same concept, some cases have been published where in case of post-op infections, the device can be treated with antibiotics locally, in order to avoid the plate removal [2,3]. 

The device is indicated both in adult and paediatric patients (for children 2 years and above of age in EMEA and 7 years and above in US). 

References

1.    Mastrogiacomo, M. et al. Role of scaffold internal structure on in vivo bone formation in macroporous calcium phosphate bioceramics. Biomaterials 27, 3230–3237 (2006).
2.    Zanotti, B., Zingaretti, N., Verlicchi, A., Alfieri, A. & Parodi, P. C. Successful Strategies for Dealing With Infected, Custom-Made Hydroxyapatite Cranioplasty. J Craniofac Surg (2018) doi:10.1097/SCS.0000000000004415.
3.    Iaccarino, C. et al. Septic complication following porous hydroxyapatite cranioplasty: prosthesis retention management. J Neurosurg Sci (2016).

Please note that outside of the US, the product is referred to as CustomBone Service. The US name for the device is CustomizedBone Service. Publication could refers to the device as CustomBone Service. Both names refer to the same device.