Recent clinical paper on CustomBone Service

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We would like to inform you about a recent clinical paper con CustomBone Service

The paper titled “The Antibiotic Immersion of Custom-Made Porous Hydroxyapatite Cranioplasty: A Multicentric Cohort Study” [1] is aimed to demonstrate the efficacy of the 20-years of experience in cranioplasty using custom-made implants made of 3D porous HA saturated with Rifampin in an attempt to prevent early implant infections.
The authors compare the population of cranioplasties without preoperative antibiotic elution and those with a non-standardised antibiotic elution.

A total of 77 cranioplasties were included in the study, along with 120 retrospective cases in comparison.
Infections occurred in 2.6% of cranioplasties with antibiotic immersion compared to 7.8% of cranioplasties without.
These results further support the hypothesis that pre-treatment of 3D porous HA implants with antibiotic appears to prevent cranioplasty infections and could be a viable option to improve cranioplasty outcomes in the future, without forgetting the association with antibiotics in the treatment of late infections [2,3].

References:
[1] F. Amendola; L. Vaienti; R. Carbonaro; A. Nataloni; A. Barbanera; N. Zingaretti; P.C. Parodi; B. Zanotti “The Antibiotic Immersion of Custom-Made Porous Hydroxyapatite Cranioplasty: A Multicentric Cohort Study” - J Craniofac Surg 2022;33: 1464–1468 https://pubmed.ncbi.nlm.nih.gov/35165242/
[2] B. Zanotti; N. Zingaretti; A. Verlicchi; A. Alfieri; P.C. Parodi: “Successful Strategies for Dealing with Infected, Custom-made Hydroxyapatite Cranioplasty”. Journal of Craniofacial Surgery. 2018 Mar 1. doi: 0.1097/SCS.0000000000004415. 2018 https://www.ncbi.nlm.nih.gov/pubmed/29498974
[3] C. Iaccarino; PP Mattogni; B. Zanotti; S. Bellochi; A. Verlicchi; E. Viaroli; G. Pastorello; F. Sgulò; R. Ghardirpour; F. Servadei: “Septic complication following porous hydroxyapatite cranioplasty: prosthesis retention management” Journal of Neurosurgical Sciences. 2016 http://www.ncbi.nlm.nih.gov/pubmed/27175619